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Association Agency from Real Medication and you may Rehab, Taipei Tzu Chi Medical, Buddhist Tzu Chi Scientific Foundation, The Taipei Town, Taiwan
Affiliations Section from Rheumatology, Allergic reaction, and you can Immunology, Agencies from Internal Medication, Kaohsiung Chang Gung Memorial Healthcare, Kaohsiung, Taiwan, Chang Gung College University of Treatments, Kaohsiung, Taiwan
Affiliations Chang Gung School College out of Treatments, Kaohsiung, Taiwan, Agencies out of Obstetrics and you can Gynecology, Kaohsiung Chang Gung Memorial Healthcare, Kaohsiung, Taiwan
Associations Department off Rheumatology, Allergy, and you can Immunology, Agency regarding Internal Medication, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, Chang Gung College or university College or university out-of Medication, Kaohsiung, Taiwan
- Fu-Mei Su,
- Dung-Huan Liu,
- Jia-Feng Chen,
- Shan-Fu Yu,
- Wen-Chan Chiu,
- Chung-Yuan Hsu,
Background
Growing an OSTAi device and you will compare that it on National Weakening of bones Basis advice within the 2013 (NOF 2013) getting bone mineral thickness (BMD) evaluation certainly thai video chat Taiwan postmenopausal women.
Strategies
Taiwan Weakening of bones Association (TOA) held a nationwide BMD questionnaire by the a coach installed having a good twin time X-ray absorptiometry (DXA) between 2008 and 2011. All the players accomplished survey, including demographics and risk affairs out-of osteoporotic fracture in the FRAX product. I made use of the database to research prospective chance affairs getting weakening of bones and you will adopted the new design of the Koh ainsi que al. growing a risk directory through several varying regression investigation and you will goods avoidance. I made use of the directory beliefs to set up a simple algorithm (particularly OSTAi) to spot people that you need BMD measurement. Person working attribute (ROC) contour and the city within the curve (AUC) was utilized to compare the fresh new sensitivity/specificity investigation regarding the design with that off guidance by the NOF 2013.
Efficiency
A maximum of a dozen,175 Taiwan postmenopausal female signed up for that it survey. The latest directory worthy of is derived by the years and the body lbs from the participants considering adjusted likelihood of for each exposure foundation and the new chose cutoff really worth are place at “-1”. You will find 6393 (52.5%) people whose directory worth try below “-1” and you will whoever chance of osteoporosis are 57.5% (). New AUC to own OSTAi and you will NOF 2013 had been 0.739 (95% believe period (CI), 0.728–0.749, P dos ), prior crack, high-risk cures explore in the reduced bones bulk otherwise bones losings (e.grams., glucocorticoid within the a regular dosages ? 5 milligrams prednisone or similar for ? 3 months), or problem or condition of limbs loss (e.g., rheumatoid arthritis symptoms). Brand new diagnostic overall performance of NOF 2013 having forecasting weakening of bones inside our analyzed populace was then reviewed.
Mathematical Investigation
I accompanied the latest statistical studies by the Koh ainsi que al. with a few amendment. The possibility exposure things having osteoporosis included in the design invention process contained the risk facts on FRAX tool, in which cultural basis wasn’t provided.